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Literature summary for 3.4.22.69 extracted from

  • Stille, J.K.; Tjutrins, J.; Wang, G.; Venegas, F.A.; Hennecker, C.; Rueda, A.M.; Sharon, I.; Blaine, N.; Miron, C.E.; Pinus, S.; Labarre, A.; Plescia, J.; Burai Patrascu, M.; Zhang, X.; Wahba, A.S.; Vlaho, D.; Huot, M.J.; Schmeing, T.M.; Mittermaier, A.K.; Moitessier, N.
    Design, synthesis and invitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors (2022), Eur. J. Med. Chem., 229, 114046 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.69

Inhibitors

Inhibitors Comment Organism Structure
2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-chlorophenethyl)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-methoxyphenethyl)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-phenylpropyl)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(4-methoxyphenethyl)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-cyclohexyl-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(1-benzylpiperidin-4-yl)-2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-1-(5-methylpyrazin-2-yl)-2-oxoethyl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl) acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-4-yl)ethyl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclopentylamino)-2-oxo-1-(pyridin-3-yl)ethyl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2
N-(4-(tert-butyl)phenyl)-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl)-4-hydroxybut-2-ynamide
-
 Severe acute respiratory syndrome coronavirus 2
N-benzyl-2-(N-(4-(tert-butyl)phenyl)-2-chloroacetamido)-2-(pyridin-3-yl)acetamide
-
 Severe acute respiratory syndrome coronavirus 2

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2
-
-
-

Synonyms

Synonyms Comment Organism
3cLpro
-
 Severe acute respiratory syndrome coronavirus 2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-chlorophenethyl)-2-(pyridin-3-yl)acetamide
0.00022
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(1-benzylpiperidin-4-yl)-2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-2-(pyridin-3-yl)acetamide
0.00024
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-methoxyphenethyl)-2-(pyridin-3-yl)acetamide
0.00028
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(4-methoxyphenethyl)-2-(pyridin-3-yl)acetamide
0.00038
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclopentylamino)-2-oxo-1-(pyridin-3-yl)ethyl)acetamide
0.00041
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl) acetamide
0.00042
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-cyclohexyl-2-(pyridin-3-yl)acetamide
0.00052
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-phenylpropyl)-2-(pyridin-3-yl)acetamide
0.00084
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-4-yl)ethyl)acetamide
0.00085
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(4-(tert-butyl)phenyl)-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl)-4-hydroxybut-2-ynamide
0.00092
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-benzyl-2-(N-(4-(tert-butyl)phenyl)-2-chloroacetamido)-2-(pyridin-3-yl)acetamide
0.00098
-
 pH 7.3, 25°C Severe acute respiratory syndrome coronavirus 2 N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-1-(5-methylpyrazin-2-yl)-2-oxoethyl)acetamide